Liquid-based cytological and immunohistochemical study of nasopharyngeal swab from persons under investigation for SARS-CoV-2 infection.

David ParadaKarla B PeñaJosep GumàCarmen GuilarteFrancesc Riu

Published in: Histopathology (2020)

SARS-CoV-2 predominantly localizes squamous cells in cytology samples of patients with RT-PCR positive determination of SARSCoV-2. The results of the current study support the notion that the nasopharyngeal region is the anatomical station that SARS-CoV-2 infects first, and the infection can lead to the migration of the virus into the lower airways.

Keyphrases

sars cov
respiratory syndrome coronavirus
high grade
cystic fibrosis
induced apoptosis
mass spectrometry
fine needle aspiration
oxidative stress
signaling pathway
high resolution
solid phase extraction
tandem mass spectrometry