Hypertension and cerebral blood flow in the development of Alzheimer's disease.
Dario BachmannAntje SaakeSandro StuderAndreas BuchmannKatrin RauenEsmeralda GruberLars MichelsRoger M NitschChristoph HockAnton GietlValerie Treyernull nullPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
Hypertension is associated with increased entorhinal cortex (EC) tau, particularly in the presence of amyloid. Decreased cortical cerebral blood flow (CBF) is associated with higher regional white matter hyperintensity volume. Increasing amyloid burden is associated with decreasing CBF in the occipital lobe. MTL CBF and amyloid are synergistically associated with EC tau.