Nucleus accumbens dopamine increases sexual motivation in sexually satiated male rats.

The optimal sexual performance of sexually experienced male rats cannot be further improved by DA receptor activation at either brain region. In sexually satiated rats, which are sexually inhibited and have a diminished sexual motivation, NAcc DA receptor stimulation appears to play a key role in their capacity to respond to a motivational significant stimulus, the receptive female, with the participation of D2-like receptors. Activation of DA receptors with the same drug, at the same dose and in the same brain region, produces different effects on copulatory behavior that depend on the animal's sexual motivational state.