Interleukin-6 promotes primitive endoderm development in bovine blastocysts.

Lydia K WooldridgeAlan D Ealy

Published in: BMC developmental biology (2021)

To conclude, IL6 manipulates ICM development after EPI/PE cell fates are established. The PE cells are the target for IL6, where a JAK-dependent signal is used to regulate PE numbers.

Keyphrases

induced apoptosis
single cell
cell cycle arrest
stem cells
oxidative stress
cell death