CircNFIB inhibits tumor growth and metastasis through suppressing MEK1/ERK signaling in intrahepatic cholangiocarcinoma.

Jinpeng DuTian LanHaotian LiaoXuping FengXing ChenWenwei LiaoGuimin HouLin XuQingbo FengKunlin XieMingheng LiaoXiangzheng ChenJiwei HuangKefei YuanYong Zeng

Published in: Molecular cancer (2022)

Our findings identified that cNFIB played a key role in ICC growth and metastasis by regulating MEK1/ERK signaling. Given the efficacy of cNFIB modulation on ICC suppression and trametinib sensitivity, cNFIB appears to be a potential therapeutic molecule for ICC treatment.

Keyphrases

pi k akt
signaling pathway
cell proliferation
smoking cessation