Sirtuin 3 Mediated by Spinal cMyc-Enhancer of Zeste Homology 2 Pathway Plays an Important Role in Human Immunodeficiency Virus-Related Neuropathic Pain Model.
Xun ZhuHyun YiJun GuShue LiuKentaro HayashiDaigo IkegamiMarta PardoMichal ToborekSabita RoyHeng LiRoy C LevittShuanglin HaoPublished in: Anesthesia and analgesia (2024)
These results demonstrated that spinal Sirt3 decrease in gp120M-induced neuropathic pain was mediated by cMyc-EZH2/H3K27me3 activity in an epigenetic manner. This study provided new insight into the mechanisms of neuropathic pain in HIV patients with chronic opioids.
Keyphrases
- neuropathic pain
- human immunodeficiency virus
- spinal cord
- antiretroviral therapy
- hepatitis c virus
- spinal cord injury
- hiv infected
- hiv positive
- hiv aids
- dna methylation
- gene expression
- oxidative stress
- high glucose
- chronic pain
- diabetic rats
- pain management
- hiv testing
- transcription factor
- binding protein
- long non coding rna
- ischemia reperfusion injury
- south africa
- stress induced
- men who have sex with men