Rh-relaxin-2 attenuates degranulation of mast cells by inhibiting NF-κB through PI3K-AKT/TNFAIP3 pathway in an experimental germinal matrix hemorrhage rat model.
Peng LiGang ZhaoFanfan ChenYan DingTianyi WangShengpeng LiuWeitian LuWeilin XuJerry FloresUmut OcakTongyu ZhangJohn H ZhangJi-Ping TangPublished in: Journal of neuroinflammation (2020)
Our findings showed that rh-relaxin-2 attenuated degranulation of mast cells and neuroinflammation, improved neurological outcomes, and ameliorated hydrocephalus after GMH through RXFP1/PI3K-AKT/TNFAIP3/NF-κB signaling pathway.
Keyphrases
- pi k akt
- signaling pathway
- cell cycle arrest
- induced apoptosis
- epithelial mesenchymal transition
- cell proliferation
- subarachnoid hemorrhage
- cerebral ischemia
- traumatic brain injury
- lipopolysaccharide induced
- type diabetes
- metabolic syndrome
- oxidative stress
- immune response
- glycemic control
- toll like receptor
- nuclear factor
- insulin resistance