Locus Coeruleus Magnetic Resonance Imaging in Neurological Diseases.
Alessandro GalganiFrancesco LombardoDaniele Della LattaNicola MartiniUbaldo BonuccelliFrancesco FornaiFilippo Sean GiorgiPublished in: Current neurology and neuroscience reports (2020)
LC-MRI findings were largely in agreement with neuropathological evidences; LC signal showed to be not significantly affected during normal aging and to correlate with cognitive performances. On the contrary, a marked reduction of LC signal was observed in patients suffering from neurodegenerative disorders, with specific features. LC-MRI is a promising tool, which may be used in the future to explore LC pathophysiology as well as an early biomarker for degenerative diseases.
Keyphrases
- simultaneous determination
- mass spectrometry
- end stage renal disease
- magnetic resonance imaging
- liquid chromatography
- ejection fraction
- chronic kidney disease
- newly diagnosed
- prognostic factors
- diffusion weighted imaging
- peritoneal dialysis
- magnetic resonance
- current status
- patient reported
- high resolution mass spectrometry
- patient reported outcomes