Reduced control of SARS-CoV-2 infection is associated with lower mucosal antibody responses in pregnant women.
Laura A St ClairRaghda E EldesoukiJaiprasath SachithanandhamAnna YinAmary FallC Paul MorrisJulie M NortonMichael FormanOmar AbdullahSantosh DhakalCaelan BarrantaHana GoldingSusan J Bersoff-MatchaCatherine Pilgrim-GraysonLeah BerhaneAndrea L CoxIrina BurdAndrew S PekoszHeba H MostafaSabra L KleinSabra L KleinPublished in: medRxiv : the preprint server for health sciences (2023)
The findings of this study provide novel evidence that, during pregnancy, lower mucosal antibody responses are associated with reduced control of SARS-CoV-2, including variants of concern, and greater disease severity, especially with increasing maternal age. Reduced mucosal antibody responses among vaccinated pregnant women highlight the need for bivalent booster doses during pregnancy.