In Vitro Transcriptome Response to a Mixture of Lactobacilli Strains in Intestinal Porcine Epithelial Cell Line.

Ionelia ȚăranuDaniela Eliza MarinCornelia BraicuGina Cecilia PistolIonut SorescuLavinia-Lorena PruteanuIoana Berindan NeagoeDan Cristian Vodnar

Published in: International journal of molecular sciences (2018)

Gene overexpression was the predominant effect produced by lactobacilli treatment in IPEC-1 cells, genes related to signaling pathways being the most affected. The protective role of lactobacilli in epithelial barrier function against inflammation and in the activation of immune response was also noticed.

Keyphrases

genome wide
induced apoptosis
immune response
signaling pathway
oxidative stress
genome wide identification
escherichia coli
cell cycle arrest
copy number
dna methylation
cell proliferation
transcription factor
endoplasmic reticulum stress
single cell
rna seq
genome wide analysis
combination therapy