Engineering Saccharomyces cerevisiae for the production and secretion of Affibody molecules.
Veronica GastAnna SandegrenFinn DunåsSiri EkbladRezan GülerStaffan ThorénMarta Tous MohedanoMikael MolinMartin K M EngqvistVerena SiewersPublished in: Microbial cell factories (2022)
This study shows that engineered S. cerevisiae has a great potential as a production host for recombinant Affibody molecules, reaching a high titer, and for proteins where endotoxin removal could be challenging, the use of S. cerevisiae obviates the need for endotoxin removal from protein produced in E. coli.