Incremental role of glycaemic variability over HbA1c in identifying type 2 diabetic patients with high platelet reactivity undergoing percutaneous coronary intervention.
Annunziata NuscaDario TuccinardiClaudio ProsciaRosetta MelfiSilvia ManfriniAntonio NicolucciAntonio CerielloPaolo PozzilliGian Paolo UssiaFrancesco GrigioniGermano Di SciascioPublished in: Cardiovascular diabetology (2019)
Glyco-metabolic state significantly correlates with HPR in well-controlled type 2 DM patients on clopidogrel therapy. HbA1c identifies patients at higher thrombotic risk but the highest diagnostic accuracy is achieved by combining GV and HbA1c. Whether individualized antithrombotic and glucose-lowering therapies based on the assessment of these parameters may reduce the incidence of thrombotic events in patients undergoing PCI should be further investigated.
Keyphrases
- percutaneous coronary intervention
- acute coronary syndrome
- antiplatelet therapy
- st segment elevation myocardial infarction
- patients undergoing
- coronary artery disease
- acute myocardial infarction
- end stage renal disease
- st elevation myocardial infarction
- type diabetes
- ejection fraction
- atrial fibrillation
- coronary artery bypass grafting
- newly diagnosed
- chronic kidney disease
- heart failure
- genome wide
- gene expression
- blood pressure
- atomic force microscopy
- insulin resistance
- skeletal muscle
- patient reported
- high resolution
- single molecule