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Complex-Forming Properties of the Anti-Inflammatory Sialorphin Derivative Palmitic Acid-Lysine-Lysine-Glutamine-Histidine-Asparagine-Proline-Arginine with Cu(II) Ions in an Aqueous Solution.

Marek PająkElżbieta KamyszKarol SikoraJakub FichnaMagdalena Woźniczka
Published in: Molecules (Basel, Switzerland) (2023)
The present work describes the complexation of the anti-inflammatory sialorphin derivative Pal-Lys-Lys-Gln-His-Asn-Pro-Arg (palmitic acid-lysine-lysine-glutamine-histidine-asparagine-proline-arginine) with Cu(II) ions in an aqueous solution, at a temperature of 25.0 ± 0.1 °C, over the whole pH range. The complexing properties were characterized by potentiometric and UV-Vis spectrophotometric methods. The potentiometric method was used to calculate the logarithms of the overall stability constants (log β ) and the values of the stepwise dissociation constants (p K a ) of the studied complexes. The percentage of each species formed in an aqueous solution was estimated from the species distribution curve as a function of pH. The absorbance ( A ) and molar absorption coefficient ( ε ) values for the Cu(II)-sialorphin derivative system were determined with UV-Vis spectroscopy. Our studies indicate that the sialorphin derivative forms stable complexes with Cu(II) ions, which may lead to future biological and therapeutic applications.
Keyphrases
  • aqueous solution
  • anti inflammatory
  • amino acid
  • nitric oxide
  • water soluble
  • high resolution
  • magnetic resonance imaging
  • current status
  • genetic diversity
  • liquid chromatography