Host genetic susceptibility underlying SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Brazilian Children.
Cíntia Barros Santos-RebouçasRafael Mina PiergiorgeCristina Dos Santos FerreiraRaquel de Seixas ZeitelAlexandra Lehmkuhl GerberMarta Cristine Felix RodriguesAna Paula de Campos GuimarãesRodrigo Moulin SilvaAdriana Rodrigues FonsecaRangel Celso SouzaAna Tereza Antunes Monteiro de SouzaÁtila Duque RossiLuís Cristóvão de Moraes Sobrino PortoCynthia Chester CardosoAna Tereza Ribeiro de VasconcelosPublished in: Molecular medicine (Cambridge, Mass.) (2022)
This study is the first to explore host MIS-C-associated variants in a Latin American admixed population. Besides expanding the spectrum of MIS-C-associated variants, our findings highlight the relevance of using WES for characterising the genetic interindividual variability associated with COVID-19 complications and ratify the presence of overlapping/convergent mechanisms among MIS-C, KD and COVID-19, crucial for future therapeutic management.