Combinations of medicines in patients with polypharmacy aged 65-100 in primary care: Large variability in risks of adverse drug related and emergency hospital admissions.

Ali Fahmi David Chi-Wai WongLauren WalkerIain BuchanMunir PirmohamedAnita SharmaHarriet CantDarren M Ashcroft Tjeerd Pieter van Staa

Published in: PloS one (2023)

Polypharmacy involves a very large number of different combinations of medicines, with substantial differences in risks of ADR-related and emergency hospital admissions. Although the medicines may not be causally related to increased risks, RF model predictions may be useful in prioritising medication reviews. Simple tools based on few medicine classes may not be effective in identifying high risk patients.

Keyphrases

adverse drug
primary care
emergency department
healthcare
human health
public health
end stage renal disease
ejection fraction
newly diagnosed
drug induced
risk assessment
peritoneal dialysis
systematic review
prognostic factors
patient reported outcomes