Effective-Component Compatibility of Bufei Yishen Formula III Suppresses Mitochondrial Oxidative Damage in COPD: Via Pkm2/Nrf2 Pathway.
Yang LiuLanxi ZhangJie ZhaoRuilong LuXuejie ShaoKexin XuJian-Sheng LiYange TianPublished in: International journal of chronic obstructive pulmonary disease (2024)
These results indicate that ECC-BYF III exerts a strong effective therapeutic effect against cigarette smoke combined with bacteria-induced COPD in rats by activating the Pkm2/Nrf2 signaling pathway and restoring mitochondrial oxidative stress. Although more in vivo animal model research is needed to confirm these findings, this study contributes new data to support the conventional usage of ECC-BYF III.
Keyphrases
- oxidative stress
- signaling pathway
- diabetic rats
- induced apoptosis
- chronic obstructive pulmonary disease
- ischemia reperfusion injury
- dna damage
- lung function
- pi k akt
- epithelial mesenchymal transition
- electronic health record
- high glucose
- human milk
- deep learning
- drug induced
- endothelial cells
- machine learning
- endoplasmic reticulum stress