Investigation of the Active Ingredients and Mechanism of Hudi Enteric-Coated Capsules in DSS-Induced Ulcerative Colitis Mice Based on Network Pharmacology and Experimental Verification.
Panghua DingJiajing LiuQiuyi LiQiongqiong LuJunxiang LiRui ShiLei ShiTangyou MaoDongyu GeHaiJun NiuGui-Ying PengZhibin WangPublished in: Drug design, development and therapy (2021)
The HDC treatment, particularly the middle-dose, exerted an anti-UC effect in a multi-component, multi-target, and multi-mechanism manner, especially inhibiting the IL-17/JAK2/STAT3 signaling pathway to downregulate the secretion of proinflammatory cytokines.