Effects of dofetilide and ranolazine on atrial fibrillatory rate in a horse model of acutely induced atrial fibrillation.

Helena CarstensenEva Zander HesselkildeMaria Mathilde HaugaardMette FlethøjJonas CarlsonSteen PehrsonThomas JespersenPyotr G PlatonovRikke Buhl

Published in: Journal of cardiovascular electrophysiology (2019)

The atrial fibrillatory rate derived from surface ECGs showed a difference in the mode of action on AF between dofetilide and ranolazine. Dofetilide reduced the atrial fibrillatory rate, whereas ranolazine displayed a cardioverting mechanism that was distinct from a slowing of the fibrillatory process.

Keyphrases

atrial fibrillation
catheter ablation
left atrial
oral anticoagulants
left atrial appendage
direct oral anticoagulants
heart failure
percutaneous coronary intervention
high glucose
left ventricular
drug induced