Extracellular Vesicles from Adipose Tissue-Derived Stromal Cells Stimulate Angiogenesis in a Scaffold-Dependent Fashion.
V E GetovaE Orozco-GarcíaS PalmersG KrenningR Narvaez-SanchezMartim Conrad HarmsenPublished in: Tissue engineering and regenerative medicine (2024)
Our study revealed that ASC-EVs augment in vitro and ex vivo vascularisation, likely due to the enriched pro-angiogenic miRNAs in EVs, particularly miR-1290. Our results show promise for regenerative and revascularisation therapies based on ASC-EV-loaded ECM hydrogels.
Keyphrases
- adipose tissue
- tissue engineering
- drug delivery
- wound healing
- stem cells
- cell proliferation
- long non coding rna
- nlrp inflammasome
- extracellular matrix
- mesenchymal stem cells
- endothelial cells
- insulin resistance
- cell therapy
- high fat diet
- single cell
- long noncoding rna
- cancer therapy
- vascular endothelial growth factor
- drug release
- metabolic syndrome
- deep learning