Comparison of in vitro Susceptibility of Mycobacteria Against PA-824 to Identify Key Residues of Ddn, the Deazoflavin-Dependent Nitroreductase from Mycobacterium tuberculosis.

Fuzhen ZhangShanshan LiShuan WenTingting ZhangYuanyuan ShangFengmin HuoYi XueLing LiYu Pang

Published in: Infection and drug resistance (2020)

Our data demonstrated that PA-824 exhibited excellent and moderate levels of in vitro activity against MTB and M. kansasii, respectively. Substitutions of Ddn residues Y65, A76 or Y133 conferred mycobacterial resistance to PA-824.

Keyphrases

mycobacterium tuberculosis
pulmonary tuberculosis
electronic health record
big data
high intensity
machine learning
artificial intelligence
deep learning