Unburned Tobacco Cigarette Smoke Alters Rat Ultrastructural Lung Airways and DNA.
Fabio VivarelliDonatella CanistroSilvia CirilloRyan J EliasSilvia GranataMatilde MussoniSabrina BurattiniElisabetta FalcieriEleonora TurriniCarmela FimognariAnnamaria BuschiniMirca LazzarettiSofia BeghiStefano GirottiStefano SangiorgiLuca BolelliSeverino GhiniElida Nora FerriIvan FagiolinoPaola FranchiMarco LucariniDario MercatanteMaria Teresa Rodriguez-EstradaAntonello LorenziniSilvia MarchionniMorena GabrieleVincenzo LongoMoreno PaoliniPublished in: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco (2022)
IQOS has been proposed as a safer alternative to conventional cigarettes, due to depressed concentration of various harmful constituents typical of traditional tobacco smoke. However, its lower health risks to consumers have yet to be determined. Our findings confirm that IQOS mainstream contains pyrolysis and thermogenic degradation by-products, the same harmful constituents of traditional cigarette smoke, and, for the first time, we show that it causes grave lung damage and promotes factors that increase cancer risk in the animal model.