Mitochondrial mutations and metabolic adaptation in pancreatic cancer.
Rae-Anne HardieEllen van DamMark CowleyTing-Li HanSeher BalabanMarina PajicMark PineseMary IconomouRobert F ShearerJessie McKennaDavid MillerNicola WaddellJohn V PearsonSean M Grimmondnull nullLeonid SazanovAndrew V BiankinSilas Villas-BoasAndrew J HoyNigel TurnerDarren N SaundersPublished in: Cancer & metabolism (2017)
The heterogeneous genomic landscape of pancreatic tumours may converge on a common metabolic phenotype, with individual tumours adapting to increased anabolic demands via different genetic mechanisms. Targeting resulting metabolic phenotypes may be a productive therapeutic strategy.