Modulation of trophoblast function by concurrent hyperglycemia and antiphospholipid antibodies is in part TLR4-dependent.
Daisy Leon-MartinezMelissa J MullaChristina S HanLawrence W ChamleyVikki M AbrahamsPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2018)
Our findings indicate that while concurrent aPL and hyperglycemia are overall detrimental to trophoblast function, the presence of two simultaneous insults triggers some protective effects.