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Iridium-Catalyzed Reductive Nucleophilic Addition to Secondary Amides.

Yoshito TakahashiRisa YoshiiTakaaki SatoNoritaka Chida
Published in: Organic letters (2018)
An iridium-catalyzed reductive nucleophilic addition to secondary amides is reported. After the iridium-catalyzed reduction, the resulting imines can undergo the Strecker reaction, the Mannich reaction, allylation, and [3 + 2]-cycloaddition. The method shows high chemoselectivity in the presence of other functional groups such as methyl ester.
Keyphrases
  • room temperature
  • electron transfer