Amygdalin Delays Cartilage Endplate Degeneration and Improves Intervertebral Disc Degeneration by Inhibiting NF-κB Signaling Pathway and Inflammatory Response.
Qinghe ZengQi SunHui-Hui XuJiali ChenHoufu LingQinwen GeKaiao ZouXu WangHongting JinJu LiMinwei JinPublished in: Journal of inflammation research (2023)
Our findings suggest that AMD partly inhibits the activation of NF-κB signaling pathway to reduce the release of inflammatory mediators and delay the degeneration of cartilage endplate in IDD model mice. Therefore, AMD may be a potential candidate for the treatment of IDD.
Keyphrases
- signaling pathway
- pi k akt
- inflammatory response
- induced apoptosis
- epithelial mesenchymal transition
- lps induced
- extracellular matrix
- lipopolysaccharide induced
- high fat diet induced
- cell proliferation
- immune response
- toll like receptor
- human health
- nuclear factor
- insulin resistance
- replacement therapy
- endoplasmic reticulum stress