Autoimmune Diabetes From Chilhood to Adulthood: The Role of Pancreatic Autoantibodies and Hla-Drb1 Genotype.

Ines Maria Urrutia Rosa Martínez Begona Calvo Laura Saso-JiménezPedro GonzálezElsa Fernández-Rubio Alicia Martín-Nieto Anibal Aguayo Itxaso Rica Sonia Gaztambide Luis Castañonull null

Published in: The Journal of clinical endocrinology and metabolism (2023)

Autoimmunity and HLA-DRB1 genotype are age-dependent biomarkers. Adult-onset autoimmune diabetes is associated with lower genetic risk and lower immune response to pancreatic islet cells compared with early-onset diabetes.

Keyphrases

early onset
type diabetes
cardiovascular disease
glycemic control
late onset
multiple sclerosis
induced apoptosis
drug induced
gene expression
early life