Lower limb bone geometry in adult individuals with X-linked hypophosphatemia: an observational study.

Matteo ScorcellettiSerhan KaraJochen ZangeJens JordanOliver SemlerEckhard SchönauJörn RittwegerAlex IrelandLothar Seefried

Published in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2022)

We observed large differences in clinically relevant measures of tibia and particularly femur bone geometry in individuals with XLH compared to controls. These differences may plausibly contribute to clinical manifestations of XLH such as early-onset osteoarthritis, pseudofractures and altered gait and therefore should be considered when planning corrective surgeries.

Keyphrases

early onset
lower limb
bone mineral density
late onset
postmenopausal women
bone loss
soft tissue
bone regeneration
rheumatoid arthritis
young adults
cerebral palsy