Differences in Prostate Cancer Genomes by Self-reported Race: Contributions of Genetic Ancestry, Modifiable Cancer Risk Factors, and Clinical Factors.
Konrad H StopsackSubhiksha NandakumarKanika AroraBastien NguyenSamantha E VasselmanBarbara NwejiSean M McBrideMichael J MorrisDana E RathkopfSusan F SlovinDaniel C DanilaKaren A AutioHoward I ScherLorelei A MucciDavid B SolitMithat GönenJuliet ChenMichael F BergerNikolaus SchultzWassim AbidaPhilip W KantoffPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Tumor genomics differed by race even after accounting for clinical characteristics. Equalizing access to care may not fully eliminate such differences. Therapies for alterations more common in racial minorities are needed. Tumor genomic differences should not be assumed to be entirely due to germline genetics.