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The effects of human pregnancy-specific β1-glycoprotein preparation on Th17 polarization of CD4+ cells and their cytokine profile.

Valeria P TimganovaSvetlana A ZamorinaLarisa S LitvinovaNatalia M TodosenkoMaria S BochkovaPavel V KhramtsovMikhail B Rayev
Published in: BMC immunology (2020)
In the experimental model used, PSG had а mainly suppressive effect on the Th17 polarization and cytokine profile of Th17-polarized CD4+ cell cultures. As Th17 activity and a pro-inflammatory cytokine background are unfavorable during pregnancy, the observed PSG effects may play a fetoprotective role in vivo.
Keyphrases
  • induced apoptosis
  • endothelial cells
  • cell cycle arrest
  • cell therapy
  • stem cells
  • signaling pathway
  • oxidative stress
  • cell death
  • mesenchymal stem cells
  • molecularly imprinted
  • mass spectrometry
  • bone marrow