Divergent Actions of Renal Tubular and Endothelial Type 1 Interleukin-1 Receptor Signaling in Toxin-induced Acute Kidney Injury.

Jiafa RenKang Liu Huijuan Mao Xiaohan Lu Lianqin Sun Jamie R Privratsky Changying XingMatthew J RobsonHuijuan Mao Randy D Blakely Koki Abe Tomokazu Souma Steven D Crowley

Published in: Journal of the American Society of Nephrology : JASN (2023)

These data highlight opposing cell-specific effects of IL-1 receptor signaling on AKI following toxin exposure. Disrupting pathways activated by IL-1R1 in the tubule, while preserving those triggered by IL-1R1 activation on endothelial cells, may afford renoprotection exceeding that of global IL-1R1 inhibition while mitigating unwanted actions of IL-1R1 blockade.

Keyphrases

acute kidney injury
endothelial cells
high glucose
escherichia coli
cardiac surgery
stem cells
artificial intelligence
diabetic rats