Gold Nanoparticles for Monitoring of Mesenchymal Stem Cell-Loaded Bioresorbable Polymeric Wraps for Arteriovenous Fistulas.
Allan John R BarcenaJoy Vanessa D PerezJossana A DamascoMarvin R BernardinoErin Marie D San ValentinCarleigh KlusmanBenjamin MartinAndrea CortesGino Martin CanlasHuckie C Del MundoFrancisco M HeraldeRony AvritscherNatalie Wall FowlkesRichard R BouchardJizhong ChengSteven Y HuangMarites P MelanconPublished in: bioRxiv : the preprint server for biology (2023)
Gold nanoparticle (AuNP)-infused perivascular wraps demonstrated higher radiopacity on micro-CT compared with wraps without AuNPs after 8 weeks.AuNP-infused perivascular wraps equally improved the wall-to-lumen ratio of the outflow vein (a marker of vascular stenosis) when compared with wraps without AuNPs, as seen on US.AuNP-infused perivascular wraps equally reduced the neointima-to-lumen ratio of the outflow vein (a measure of neointimal hyperplasia) when compared with wraps without AuNPs, as seen on histomorphometry.