Human embryonic stem cell-derived mesenchymal stromal cells ameliorate collagen-induced arthritis by inducing host-derived indoleamine 2,3 dioxygenase.

Elena Gonzalo-GilMaría J Pérez-LorenzoMaría GalindoRafael Díaz de la GuardiaBelén López-MillánClara BuenoPablo MenéndezJosé L PablosGabriel Criado

Published in: Arthritis research & therapy (2016)

Treatment with hESC-MSC ameliorates CIA by inducing IFNγ(+) Th1 cells and IDO1 in the host. Thus, hESC-MSC can provide an infinite cellular source for treatment of rheumatoid arthritis.

Keyphrases

rheumatoid arthritis
stem cells
endothelial cells
bone marrow
immune response
disease activity
systemic lupus erythematosus
cell proliferation
mouse model
high glucose
combination therapy
mesenchymal stem cells
oxidative stress
replacement therapy
signaling pathway