Corneal keratocytes, fibroblasts, and myofibroblasts exhibit distinct transcriptional profiles in vitro .
Kara PooleKrithika S IyerDavid W SchmidtkeWalter Matthew PetrollVictor D VarnerPublished in: bioRxiv : the preprint server for biology (2024)
Overall, these data demonstrate distinct transcriptional differences among cultured corneal keratocytes, fibroblasts, and myofibroblasts. We have identified genes and signaling pathways that may play important roles in keratocyte differentiation, including many related to mechanotransduction and ECM biology. Our findings have revealed novel molecular markers for each cell type, as well as possible targets for modulating cell behavior and promoting physiological corneal wound healing.
Keyphrases
- wound healing
- signaling pathway
- extracellular matrix
- optical coherence tomography
- single cell
- gene expression
- transcription factor
- cataract surgery
- endothelial cells
- genome wide
- cell therapy
- electronic health record
- stem cells
- machine learning
- oxidative stress
- induced apoptosis
- mesenchymal stem cells
- cell proliferation