Chromatin lncRNA Platr10 controls stem cell pluripotency by coordinating an intrachromosomal regulatory network.

Zhonghua DuXue WenYichen WangLin JiaShilin ZhangYudi LiuLei ZhouHui LiWang YangCong WangJingcheng ChenYajing HaoDaniela Salgado FigueroaHuiling ChenDan LiNaifei ChenIlkay CelikYanbo ZhuZi YanChanghao FuShanshan LiuBenzheng JiaoZhuo WangHui ZhangGünhan GülsoyJianjun LuoBaoming QinSujun GaoPhilipp KapranovMiguel A EstebanSongling ZhangWei LiFerhat AyRunsheng ChenAndrew R HoffmanJiuwei CuiJi-Fan Hu

Published in: Genome biology (2021)

These data suggest that Platr10 functions as a novel chromatin RNA molecule to control pluripotency in trans by modulating chromatin architecture and regulating DNA methylation in the core stem cell factor network.

Keyphrases

stem cells
genome wide
transcription factor
gene expression
dna methylation
dna damage
embryonic stem cells
signaling pathway
electronic health record
cell therapy
big data
oxidative stress
copy number
machine learning
network analysis
bone marrow
mesenchymal stem cells
artificial intelligence