Vascular injury activates the ELK1/SND1/SRF pathway to promote vascular smooth muscle cell proliferative phenotype and neointimal hyperplasia.

Chao SuMingxia LiuXuyang YaoWei HaoJinzheng MaYuanyuan RenXingjie GaoLingbiao XinLin GeYing YuMinxin WeiJie Yang

Published in: Cellular and molecular life sciences : CMLS (2024)

The present study identifies ELK1/SND1/SRF as a novel pathway in promoting the proliferative VSMC phenotype and neointimal hyperplasia in vascular injury, predisposing the vessels to pathological remodeling. This provides a potential therapeutic target for vascular stenosis.

Keyphrases

smooth muscle
single cell
genome wide
vascular smooth muscle cells
stem cells
dna methylation
risk assessment
bone marrow