Accuracy of different Xpert MTB/Rif implementation strategies in programmatic settings at the regional referral hospitals in Uganda: Evidence for country wide roll out.
Winters MuttambaWilly SsengoobaRogers SekibiraBruce KirengaAchilles KatambaMoses JolobaPublished in: PloS one (2018)
Xpert MTB/RIF has a higher sensitivity than FM both in general population and HIV positive population. Xpert MTB/RIF offers a significant increase in terms of diagnostic sensitivity even when it is deployed selectively i.e. among smear negative presumptive TB patients. Our results support frontline use of Xpert MTB/RIF assay in high HIV/TB prevalent countries. In settings with limited access, mechanisms to refer smear negative sputum samples to Xpert MTB/RIF hubs are recommended.
Keyphrases
- pulmonary tuberculosis
- mycobacterium tuberculosis
- hiv positive
- antiretroviral therapy
- men who have sex with men
- south africa
- end stage renal disease
- primary care
- human immunodeficiency virus
- hiv testing
- hiv infected
- chronic kidney disease
- newly diagnosed
- hiv aids
- peritoneal dialysis
- hepatitis c virus
- patient reported outcomes
- quality improvement
- cystic fibrosis
- patient reported