Nose-to-Brain Drug Delivery and Physico-Chemical Properties of Nanosystems: Analysis and Correlation Studies of Data from Scientific Literature.

Angela BonaccorsoAlessandro OrtisTeresa MusumeciClaudia CarboneMazhar HussainValentina Di SalvatoreSebastiano BattiatoFrancesco PappalardoRosario Pignatello

Published in: International journal of nanomedicine (2024)

A literature review revealed that nose-to-brain delivery has been widely investigated in neurodegenerative diseases. Correlation studies between the physicochemical properties of nanosystems (mean size and ZP) and DTE/DTP parameters suggest that ZP may be more significant than particle size for DTP/DTE predictability.

Keyphrases

drug delivery
resting state
white matter
case control
systematic review
functional connectivity
cerebral ischemia
electronic health record
multiple sclerosis
big data
atomic force microscopy
brain injury
high resolution
data analysis
single molecule