Differential effect of endogenous glucagon-like peptide-1 on prandial glucose counterregulatory response to hypoglycaemia in humans with and without bariatric surgery.

Henri Honka Francesco RubinoSamantha PezzicaRichard PetersonRalph A De FronzoMarzieh Salehi

Published in: Diabetes, obesity & metabolism (2024)

These results indicate that impaired post-meal glucose counterregulatory response to hypoglycaemia after GB is partly mediated by endogenous GLP-1, highlighting a novel pathogenic mechanism of GLP-1 in developing hypoglycaemia in this population.

Keyphrases

type diabetes
bariatric surgery
blood glucose
weight loss
obese patients
glycemic control
blood pressure
metabolic syndrome
skeletal muscle