Real-world outcomes treating patients with advanced cutaneous squamous cell carcinoma with immune checkpoint inhibitors (CPI).

Glenn J HannaEmily S RuizNicole R LeBoeufManisha ThakuriaChrysalyne D SchmultsJames A DecaprioAnn W Silk

Published in: British journal of cancer (2020)

We demonstrate comparatively lower response rates to CPI among real-world cSCC patients not explained by older age or immunosuppression history alone. Immune-related toxicity, absolute lymphocyte count and TMB predicted CPI response.

Keyphrases

squamous cell carcinoma
end stage renal disease
chronic kidney disease
newly diagnosed
ejection fraction
peripheral blood
oxidative stress
prognostic factors
middle aged
adipose tissue
skeletal muscle
insulin resistance
lymph node metastasis