Fibrosis of extracellular matrix is related to the duration of the disease but is unrelated to the dynamics of collagen metabolism in dilated cardiomyopathy.
Pawel P RubisSylwia Wiśniowska-ŚmialekEwa WypasekBarbara Biernacka-FijalkowskaLucyna Rudnicka-SosinEwa DziewieckaPatrycja FaltynLusine KhachatryanAleksandra KarabinowskaArtur KozaneckiLidia Tomkiewicz-PająkPiotr PodolecPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2016)
Dynamics of ECM turnover in DCM is high, which is reflected by the increased levels CTGF and degradation enzymes. Synthesis of collagen type III prevailed over collagen type I. ECM metabolism was not different in DCM regardless of the duration of the disease and status of myocardial fibrosis. Serum markers of ECM metabolism were found not to be useful for the prediction of myocardial fibrosis in DCM.