Splenectomy-Induced Leukocytosis Promotes Intratumoral Accumulation of Myeloid-Derived Suppressor Cells, Angiogenesis and Metastasis.

Murat SevmisDigdem Yoyen-ErmisCisel AydinElif BilgicPetek KorkusuzAysegul UnerErhan HamalogluGüneş EsendağliDerya Karakoc

Published in: Immunological investigations (2018)

Our data demonstrated a link among splenectomy-induced leukocytosis, accumulation of circulating and tumor-infiltrating MDSC, and enhanced angiogenesis and metastasis. Therefore, as a part of oncological surgery, favorable and unfavorable facets of the splenectomy must be considered to improve therapeutic efficacy.

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