Chemotherapy-induced oral mucositis is associated with detrimental bacterial dysbiosis.
Bo-Young HongTakanori SobueLinda ChoquetteAmanda K DupuyAngela ThompsonJoseph A BurlesonAndrew L SalnerPeter K SchauerPujan JoshiEvan FoxDong-Guk ShinGeorge M WeinstockLinda D StrausbaughAnna Dongari-BagtzoglouDouglas E PetersonPatricia I DiazPublished in: Microbiome (2019)
Altogether, our work reveals that chemotherapy-induced oral mucositis is associated with bacterial dysbiosis and demonstrates the potential for dysbiotic shifts to aggravate antineoplastic-induced epithelial injury. These findings suggest that control of oral bacterial dysbiosis could represent a novel preventive approach to ameliorate oral mucositis.