Central giant cell granulomas of the jaws stromal cells harbour mutations and have osteogenic differentiation capacity, in vivo and in vitro.
Lucyene MiguitaJuliana Cristina de SouzaVictor Coutinho BastosNubia Braga PereiraRaphaela Alvarenga Braga de FreitasLeticia Martins GuimarãesGleide Fernandes de AvelarLuciana Oliveira AndradeWalderez Ornelas DutraFabio Daumas NunesWagner Henriques CastroJulio Cesar Tanos de LacerdaAmanda Maria Sena ReisVanessa Fátima BernardesMarina Gonçalves DinizRicardo Santiago GomezCarolina Cavaliéri GomesPublished in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2022)
Collectively, the results confirm that the signature mutations are restricted to stromal cells in CGCG, and the in vitro and in vivo results support that these cells have the capacity to differentiate into osteoblasts, in line with the bone formation often observed in the stroma of these lesions.