Impact of haemolysis on vancomycin disposition in a full-term neonate treated with extracorporeal membrane oxygenation.
Pavla PokornáMartin SimaDick TibboelOndřej SlanařPublished in: Perfusion (2020)
Vancomycin elimination may be severely prolonged due to ECMO-induced haemolysis and acute kidney injury, while hypothesis of direct increase of vancomycin levels by releasing the drug from blood cells during haemolysis has been disproved.
Keyphrases
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- methicillin resistant staphylococcus aureus
- acute kidney injury
- respiratory failure
- induced apoptosis
- cardiac surgery
- drug induced
- cell cycle arrest
- high glucose
- diabetic rats
- preterm infants
- staphylococcus aureus
- mechanical ventilation
- oxidative stress
- intensive care unit
- signaling pathway
- emergency department
- cell proliferation