Hypoxia Upregulates NOTCH3 Signaling Pathway to Promote Endothelial-Mesenchymal Transition in Pulmonary Artery Endothelial Cells.

Li-Le Wang Xiao-Li Zhu Shu-Hua Han Lu Xu

Published in: Evidence-based complementary and alternative medicine : eCAM (2021)

Hypoxia promotes the transformation of endothelial cells into mesenchymal cells by opening the NOTCH3 pathway, which lays the foundation for disease progression or clinical prognosis, and is of great significance in the treatment of diseases.

Keyphrases

endothelial cells
pulmonary artery
induced apoptosis
coronary artery
signaling pathway
pulmonary hypertension
high glucose
pulmonary arterial hypertension
bone marrow
stem cells
cell proliferation
vascular endothelial growth factor
cell cycle arrest
pi k akt
endoplasmic reticulum stress
oxidative stress