Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights?
Benedikt DitzJeunard G BoekhoudtHananeh AlieeFabian J TheisMartijn C NawijnCorry-Anke BrandsmaPieter S HiemstraHidde J HaismaGaik W TewMichele A GrimbaldestonMargaret NeighborsVictor GuryevMaarten van den BergeAlen FaizPublished in: ERJ open research (2021)
More DEGs are detected by RNA-Seq than microarrays in COPD lung biopsies and are associated with immunological pathways. Performing bulk tissue cell-type deconvolution in microarray lung samples, using the SVR method, reflects RNA-Seq results. https://bit.ly/2N8sY3s.
Keyphrases
- rna seq
- single cell
- gene expression
- genome wide
- chronic obstructive pulmonary disease
- end stage renal disease
- dna methylation
- lung function
- newly diagnosed
- chronic kidney disease
- cystic fibrosis
- peritoneal dialysis
- prognostic factors
- ultrasound guided
- patient reported outcomes
- combination therapy
- air pollution
- copy number