Effects of modified lipoproteins on human trophoblast cells: a role in pre-eclampsia in pregnancies complicated by diabetes.
Rebecca Helen McLeeseJiawu ZhaoDongxu FuJeremy Y YuDerek P BrazilTimothy J LyonsPublished in: BMJ open diabetes research & care (2021)
These findings may explain, in part, the high risk for PE in women with diabetes. The trophoblast culture model has potential for evaluating novel therapies targeting barrier dysfunction.
Keyphrases
- type diabetes
- cardiovascular disease
- glycemic control
- induced apoptosis
- endothelial cells
- cell cycle arrest
- oxidative stress
- induced pluripotent stem cells
- signaling pathway
- cell death
- endoplasmic reticulum stress
- metabolic syndrome
- pregnant women
- adipose tissue
- gestational age
- climate change
- risk assessment
- weight loss
- pregnancy outcomes