Biomarkers Assessing the Role of Cumulus Cells on IVF Outcomes: A Systematic Review.

Gaelle MassoudMarcus SpannKamaria Cayton VaughtSamarjit DasMark DowRichard CochranValerie BakerJames SegarsBhuchitra Singh

Published in: Journal of assisted reproduction and genetics (2023)

Genetic biomarkers from cumulus cells were associated with oocyte quality (CAMK1D, PFKP, HAS2, VCAN, GDF-9, BMP-15, PTGS2), embryo quality (GREM1, PTGS2, HAS2), and pregnancy rate (GDF9, BMP15, VCAN). These results might help guide future studies directed at tests of cumulus cells to devise objective criteria to predict IVF outcomes.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
cell death
metabolic syndrome
dna methylation
pregnant women
case control