Including non-concurrent control patients in the analysis of platform trials: is it worth it?

Published in: BMC medical research methodology (2020)

If strict error rate control is required then non-concurrent control data should not be used; otherwise it may be beneficial if the trend is sufficiently small. On the other hand, the root mean squared error of the estimated treatment effect can be improved through using non-concurrent control data.

Keyphrases

locally advanced
electronic health record
newly diagnosed
big data
squamous cell carcinoma
machine learning
radiation therapy
data analysis
peritoneal dialysis