Clinical characteristics and HLA associations of azithromycin-induced liver injury.

Caroline ConlonYi-Ju LiJawad AhmadHuiman BarnhartRobert J FontanaMarwan S GhabrilPaul H HayashiDavid E KleinerWilliam M LeeVictor NavarroJoseph A OdinElizabeth J PhillipsAndrew StolzRaj K VuppalanchiDina Halegoua-DeMarzionull null

Published in: Alimentary pharmacology & therapeutics (2024)

Azithromycin therapy can lead to rapid onset of severe hepatic morbidity and mortality in adult and paediatric populations. Hepatocellular injury and younger age were associated with worse outcomes. HLA-DQA1*03:01 was significantly more common in AZ cases compared to controls.

Keyphrases

intensive care unit
emergency department
loop mediated isothermal amplification
type diabetes
metabolic syndrome
adipose tissue
insulin resistance
replacement therapy